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Insights Through Inductively Coupled Plasma Mass Spectroscopy (ICPMS)

Measure the elemental composition of your sample with one of the most sensitive multiple-element analysis methods available.

Get Expert Analysis of Your Material

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What is Inductively Coupled Plasma Mass Spectroscopy (ICPMS)?

 

Inductively Coupled Plasma Mass Spectroscopy (ICPMS) is a process by which an inert gas (argon) is inductively heated via current through a surrounding electromagnetic coil to form a plasma. 

The sample (typically in liquid form) is inserted, aerosolized, and digested in the plasma into ion fragments, which are accelerated through a quadrupole mass analyzer to yield a mass spectrum. 

Peaks in this spectrum correspond to the elemental ions present in the original sample, yielding quantitative and semi-quantitative elemental composition information. 

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Our Process

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Plasma Formation

An inert gas (argon) is inductively heated via current to form a plasma.

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Sample Introduction

The sample (typically in liquid form) is inserted, aerosolized and digested in the plasma into ion fragments.

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Quadrupole Mass Analysis

Ion fragments are accelerated through a quadrupole mass analyzer to yield a mass spectrum.

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Data Analysis

Peaks in the resulting mass spectrum correspond to the elemental ions present in the original sample, yielding elemental composition information.

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ICPMS Instrument Used

ThermoFisher Scientific iCAP Triple-Quad (TQ) ICP-MS

  • Detection Limits vary by atomic species: as low as < 0.5 (ng/L)b (for 9Be)
  • Abundance Sensitivity: < 0.005 ppm
  • Minimum Dwell Time: 100 μs in pulse and analog
  • Dynamic Range: more than 10 orders of magnitude
  • Stability: below 2.0 %RSD over 10 minutes
  • Isotopic Ratio Precision: below 0.1 %RSD
  • Nebulizer: Concentric glass
  • Nebulizer Default Flow Rate: 400 uL/min (pumped)
Thermo-Scientific-iCAP-TQ-ICP-MS

Strengths

  • Extremely high elemental sensitivity: limit on the order of parts-per-trillion
  • Can detect most elements in the periodic table with a single experiment
  • Accepts a wide array of sample types (solution or solid, inorganic or organic, simple composition to complex mixtures)
  • Rapid analysis
  • Isotope detection

Limitations

  • Quantitative analysis requires parallel measurement on reference / control sample
  • Does not easily capture molecular / compound information
  • Destructive
  • Sample preparation such as sample digestion via acid can be time-consuming
  • Limited total dissolved solids (TDS) tolerance

Learn More About Using Gas Chromatography Mass Spectroscopy Today!